الفهرس 
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Abstract
A simple, three component, highly efficient green synthesis of thiazolo-(3,2-aJ pyridine derivatives under neat conditions.
The present work includes the green synthesis of thiazolo [3, 2-aJ pyridines under neat conditions. When a mixture of mononitrile, aromatic aldehydes and mercaptoacetic acid in the presence of piperidine (2 DROPs) was fused for 30-60 seconds, a mixture of two products were obtained (TLC and MS) in which these structures were determined by I HNMR spectra which reflects the effect of the reactants molar ratio on Th nature of the end product. With a molar ratio of 2: I: 1.2 of reactants. Mainly product I were obtained. However, changing the molar ratio to 2: 2.2: I yields product V
The structures of I and V was established based on analytical and spectral data which confirm thaizolo [3, 2-a] pyridine structure rather than the alternative pyranothiazole VI.
heat! i . 2:1:1.2
A~
eN )-{-NH2
s00
Ar) V
heat! i 2:2.2:1
English Summary
nfirmed by 631 G. It was K collmol.
Green, three component highly efficient synthesis
of 2-amino-S,6,7,8- tetrahydro-4-H-chromcn-3-carbonitrilcs in water at ambient temperature
In this part, a green synthesis of 2-amino- 5, 6 7,8-tetrahydro 4H- chromen h3- carbonitriles in water at ambient temperature was reported. When a mixture of benzaldehyd 1, malononitrile 2, dimedone 3 in water (20 ml) in the presence of two
DROPs of piperidine as a catalyst was stirred at room temp. (226) the corresponding 2-
aminochromene derivative was obtained instanteously in 95% yield. The Mechanism to account for the formation of the product was demonstrated in scheme (I).