الفهرس 
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Abstract
Epilepsy represents a relatively common disease that may affect any age and may persist life-long.
The disease itself and the drugs used in its treatment were found to affect the different body system and function.
A nutritional assessment is important in control the epilepsy and prevent its complications occur during managing patients with epilepsy,
as there is a great risk of weight changes, particularly weight gain with some antiepileptic medications. Weight gain is not only a cosmetic problem that leads to non-compliance to medications but also increases the risk for atherosclerosis and its related complications.
The mechanisms underlying weight gain in epilepsy are multiple and controversial and have been attributed to the effect of epilepsy and more commonly the effect of antiepileptic medications on the central and peripheral mechanisms regulating weight homeostasis including the two main homeostatic hormones leptin and insulin
In our study, the knowledge of the novel roles of insulin in patients with epilepsy will help as early markers for the related adverse weight changes, thus allowing proper characterization of suitable antiepileptic medication as initial step during management and follow up of patients.
Aim of the work:
Study the nutritional status ,BMI and insulin serum level in epileptic children to determine the cause either due to epilepsy itself or antiepileptic drugs.
Patients and Methods:
To approach our goal 3 groups are taken:
Group І: it included 15 epileptic children controlled on AEDs
less than 1 year.
Group II: it included 30 epileptic children controlled on AEDs more than 1 year.
Group III: it included 15 healthy children as controls.
All subjects included were submitted to full history taking thorough clinical examination including neurological examinations and Anthropometric examination (weigh, height, BMI)The following tests were done for patients and control Hemoglobin measurement, Serum electrolytes (Na, K and Ca) and fasting insulin serum level.
The following tests were done for the patients:
• Neurophysiology: interictal EEG By Ebneuro-galilio-sirius serial no.01139
• Neuroimaging :CT brain and MRI brain.
Results :
The results of the present study can be summarized in the following points: .
• As regard weight; it showed significant increase among epileptic patients receiving valproate than multi-drugs treated patients in group I, with insignificant difference between valporate and multi-drugs treated patients in group II and control
• The study reaveled that BMI showed significant increase in epileptic children treated with valporat therapy in group II than other groups.
• The findings of this study proved that fasting insulin serum
level was significant increase among epileptic children receiving valproate in both groups than multi-drugs treated patient.
• On studying the relation between BMI and fasting insulin serum levels the study shows that in group1 there is significant increase among overweight epileptic children than normal ,
while show insignificance difference in group II .
• By analyzing data by roc curve, measurement of fasting insulin level represent a sensitive test in evaluation nutritional status in epileptic children (especially in < 1year studied patients).