الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Background: HCV is a world wide public health problem, it is estimated that about 170 million people in the world, and about 20 million of the Egyptian population are infected with this virus. Some infectious agents may cause cellular and molecular changes that contribute to the pathogenesis of atherosclerosis.
Aim of the work: To study the angiographic pattern of CAD in patients with chronic HCV infection, study the response of those patients to PCI and to correlate these changes with some clinical and laboratory abnormalities in these group of patients.
Method: we studied 50 patients of both genders admitted to Mansoura specialized medical Hospital presented with ACS eligible for coronary angiography, where they were subjected to full clinical evaluation; 12 lead electrocardiogram, full laboratory investigations including serology assay for HCV and complete platelet study (platelet count, MPV &MRPA). Coronary angiography± PCI was done to every patient, then we study the angiographic pattern and severity of CAD and study the response of those patients to percutaneous coronary intervention (PCI) and correlate these changes with some clinical and laboratory abnormalities. Those patients were classified into two main groups, the first group of patients were those with HCV +ve serology (25 patients) while the second one included patients with -ve serology for HCV (25 patients).
Results: HCV seropositive patient had a worse long term outcome than HCV seronegative patient (but statistically non-significant), and the risk become higher especially if it associated with other traditional risk factors. a significant low platelet count in HCV seropositive patient in comparison with HCV seronegative patients is associated with significant increase in the mean platelet volume (MPV), to compensates the platelet mass, also there is increase the max. Rate of platelet aggregation in that patient but not statistically significant.
Conclusions: HCV seropositivity is independent predictors of increased severity of atherosclerosis. Furthermore, having HCV seropositivity was still a strong independent predictor for the severity of coronary atherosclerosis in multivariate adjusted analysis. Patients with HCV seropositivity had more extensive, severe atherosclerosis than the control group.