الفهرس 
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Abstract
investigated. Two P. papatasi sand fly aliquots originating from Suez Governorate, Egypt were membrane fed on homogenized hamster’s lesion infected with L. major, MHOM/EG/06/RTC-63 (Northern Sinai), and L. tropica, MGER/EG/06/RTC-74 identified from patients with suspected cutaneous leishmaniasis (CL) in Northern Sinai, Egypt. Promastigotes of L. major were observed intensively in the midgut in the days 1 and 2, disappeared in the days 3 and 4 and reappeared in the latest days. On the other hand, promastigotes of L. tropica were observed intensively in the midgut in the days 1, 2 and 3, and then disappeared. Feeding rate of P. papatasi on L. major (58.69%) was higher than on L. tropica (45.99 %). Infection rate with L. major (60.19%) was significantly higher than with L. tropica (39.73%). 120 days following exposure to the infected sand flies, a leishmanial lesion was observed on foot pads of a healthy hamster. It is therefore concluded that P. papatasi is a much more effective vector for L. major than for L. tropica. Phlebotomus papatasi and P. sergenti females were experimentally infected by L. major promastigotes mixed with blood and offered to them through chick skin membrane. In general, both species were significantly susceptible to L. major. Phlebotomus papatasi was more susceptible to the infection with L. major than P. sergenti with mean infection rates of 19.16 % and 6.56 % respectively. Infection with L. major did not show any significant effect on the gonotrophic cycle of P. papatasi females, egg incubation period, hatching rate, pupation rate and adult emergence rate. A significant reduction in the number of eggs laid by infected females was recorded as well as the mean adult emergence periods. An elongation in the larval developmental period and the pupation period was recorded as a result of L. major infection. The male: female sex ratios were close to the expected 1:1 ratio. There were considerable interspecific variations in the size, shape and numbers of the pharyngeal armatures of P. papatasi and P. sergenti (susceptible species) and Sergentomyia squamipleuris and Sergentomyia chrestophersi (refractory species). The mean probing time was 7.09 mn. and the mean engorgement time was 5.86 mn.
Key words: Sand fly, Phlebotomus papatasi, P. sergenti, Sergentomyia squamipleuris, S. chrestophersi, Leishmania tropica, L. major, leishmanial lesion, experimental infection, biological parameters, pharyngeal armatures, probing, engorgement.
546. تبصرة اللغة ## a)