الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Retrieval of immature human oocytes followed by Matuartiori in vitro of oocyies been investigated in different mammalian species, and has not only resulted in embryonic development, but has also been applied commercially, such as the improvement of fertility in cattle
However the pregnancy rates with IVM are still Io\\ in comparison to in-vivo matured oocytes obtained during gonadotropine stimulated cycles/1
So it has been questioned whether inadequate or incomplete cytoplasmic maturation of oocytes leading to developmentally incompetent embryos contributes to ihehigh incidence of pregnancy failure in most of the previous studies.
This can mainly be attributed to uie relatively lower number of oocyves that mature, fertilize and finally develop successful into embryos that implant. Nevertheless, it is worthwhile to cany on further investigations since IVM offers a number of advantages, it would enable a decrease in the use of ovarian stimulation drugs in ilormo-and anovulatory patients, especially those with polycystic ovarie (PCOS)1 who are at risk of developing ovarian hyperstiinulation, also it reduces the coasts and relief anxiety over the potential long term side effects of ovarian stimulation drugs, as a variable number of oocytes on stimulation has to be cancelled, either due to the risk of hyperstimulatien or to delay response. So in-vitro maturation, fertilization and embryo transfer may provide an alternative to cancellation of these cycles.
Moreover, the development of this technique could provide a new strategy m assisted reproduction, enabling to minimize the concerns about a possible association between the use of u\oilation inducing drugs and the increased risk of ovarian cancer.