الفهرس 
INTERSTITIAL LUNG DISEASESOnly 14 pages are availabe for public view
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Abstract
CLDs in children are chronic inflammation of the
airways and other parts of the lung .Omega 3 fatty acids competitive
inhibit the formation of LTB-4 and PG from arachidonic acids.
Aim: Assess the role of Omega-3 fatty acids supplementation in
treatment of chronic lung diseased children in Egypt..
Methods: Our study was conducted on 20 children with chronic
lung disease and 10 healthy children as control .Each child had taken
300 mg DHA and 700 mg EPA for 60 days. Serum level of DHA was
measured by HPLC method as well as PFTs were measured before and
after supplementation.
Results: The serum level of DHA and PFTs were significantly
lower in chronic lung diseased children compared to controls before
and after intake of DHA supplementation. The highly significant
increase in the mean value of DHA serum level in the cases after
supplementation (10.2±0.7 μg/ml), was associated with highly
significant increase in the mean value of FVC and FEV1after
supplementation.Serum level of DHA was significantly positively
correlated to PFTs ( FVC and FEV1).
Conclusion: Omege-3 fatty acids dietary supplementation is a
promising tool and may provide a valuable adjunct therapeutic
modality for treatment of pediatric chronic lung diseases for future
longitudinal assessment.