الفهرس 
CHAPTER 1 INTRODUCTION & AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
DM represents the major public health disease affecting different body organs. Al and its compounds comprise about 8% of the Earth’s surface; Al occurs naturally in silicates, cryolite, and bauxite rock. Natural processes account for most of the redistribution of Al in the
environment. Acidic precipitation mobilizes Al from natural sources, and
direct anthropogenic releases of Al compounds associated with industrial
processes occur mainly to air. Certain uses lead to the presence of Al in
drinking water and foodstuffs. Al compounds are used as food additives
and in the manufacture of abrasives, refractories, ceramics, electrical
insulators, catalysts, paper, spark plugs, light bulbs, artificial gems,
alloys, glass and heat resistant fibres, pharmaceutical and personal care
products, preservatives, fillers, colouring agents, anti-caking agents,
emulsifiers and baking powders and soy-based infant formula can
contain Al. Diabetes and Al intoxication possess the major health
problems especially during pregnancy and development of child.
One hundred and sixty-eight fertile male and virgin female rats
were used for experimentation. Females were mated in a special cage
(1male/3 females) during overnight and gestation was determined in the
next morning by the presence of sperm in a native vaginal smear. The
pregnant rats were arranged into eight groups; control, Morus alba treated
group, experimental diabetic, Diabetic and Morus alba , Al-intoxicated
group , Morus alba and Al intoxicated group, Experimental diabetic and
Al intoxicated group and Morus alba plus diabetic and Al intoxicated
group. Each of the experimental groups was sacrificed at parturition, 7, 9
& 14 days-old. Fast blood glucose was determined in maternal serum. Al
levels were estimated in sera & cerebellum of mothers as well as
cerebellum of 14 days old pups of both control and experimental groups.
CHAPTER VI SUMMARY
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Cerebellum, spinal cord & retinal of both control and experimental
groups of the mentioned aging pups were subjected for light & TEM,
DNA fragmentation & comet assay investigations.
Phytotherapy is frequently used throughout the world for a range of
diabetic presentations and considered to be less toxic and free from side
effects than synthetic drugs. Therefore, investigations of such medicines
have become particularly important. Morus alba (Mulberry tree) of the
family Moraceae has been widely cultivated in countries worldwide from
temperate to tropical areas.
The findings of the present study are summarized as follows:
1. SDS-PAGE phytochemistry:
Qualitative &quantitative analyses of protein compounds exhibited
obvious similarities in the expression of bands between water and ethyl
alcohol extracts of leaves, non-ripened fruits, ripened fruits and bark of
Morus alba L. Comparing lanes revealed a close similarities of protein
band patterns of different extractions .
2. Body weight of pups:
The body weight of pups maternally subjected to diabetes and/or
intoxicated with Al which showed that pups maternally diabetic at 1, 7
and 14 days-old had overgrowth weight (macrosomia) comparing with
marked depletion of body weight in pups maternally intoxicated with
aluminum. Treatment with Morus alba extract led to a marked
amelioration of body weight but was still above the normal levels in
diabetic group comparing with pups maternally intoxicated with
aluminum.
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