الفهرس 
REVIEW OF LITERATURESOnly 14 pages are availabe for public view
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Abstract
Kidney transplantation is the treatment of choice for end stage renal disease, there are different immune mechanisms involved in the pathogenesis of acute rejection and graft loss. Many genes are contributed to immunological acceptance of the graft are human leukocyte antigen (HLA) genes. Also other non- HLA gene polymorphisms may predict the future risk of complications.
The present study was conducted on 100 couples of end stage renal disease (recipients and their donors) who were admitted to the Urology & Nephrology Center, Mansoura University in the period of 2005 to 2010. There were 50% matching in HLA alleles between all recipients and their donors.
The subjects of the study were divided into two groups according to the percentage of matching in DRB1 suballeles between recipients and their donors. Fifty couples were found to be identical in DRB1* suballeles and the fifity couples mismatched in DRB1* suballeles. All subjects were subjected to full history, clinical examination, complete routine laboratory and radiological investigation.
The following results were obtained:
There was no statistical significant difference between the two groups as regard age and consanguinity.
There was no significant difference between the suballeles matching and incidence rejection.
The frequency of rejection episodes has no impact no outcome among both groups as the % of those suffering from repeated rejection.