الفهرس 
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Abstract
The purpose of this study was to investigate the comparative effects of oral metformin (100 mg/ kg body weight), rosiglitazone (4mg /kg body weight), and/or selenium (0.1ppm) for 6 weeks on serum glucose, total cholesterol, triglyceride, high density lipoprotein-cholesterol, nonesterified fatty acids concentrations, and plasma malondialdehyde and blood glutathione concentrations and hepatic glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, and glutathione peroxidase activity in streptozotocin-induced diabetic rats (50mg/kg body weight). Induction of diabetes resulted in an increase of all the parameters studied except serum high density lipoprotein-cholesterol levels, blood glutathione levels, hepatic glucose-6-phosphate dehydrogenase activity, and hepatic glutathione peroxidase activity that were markedly decreased as compared to normal controls. Treatment of diabetic rats with either metformin, rosiglitazone, and/or selenium corrected most of these changes. In conclusion, the results of this study suggest that rosiglitazone, metformin, and/or selenium seem to be involved in relieving the oxidative stress, modulating the changes in serum lipid levels in diabetic rats, in addition to the insulin like effects of selenium.