الفهرس 
Peptic Ulcer DiseaseOnly 14 pages are availabe for public view
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Abstract
This study was conducted to asses factors affecting development of peptic ulcer in cirrhotic patient. A total of 60(sixty) cirrhotic patients and 20(twenty) dyspeptic patients were enrolled in the study during 9-month study period. All of them had symptoms suggestive of peptic ulcer disease. They underwent upper GI endoscopy and then patients were divided into three groups. Group(I) included 45 patients (29 male &16 female) with cirrhosis and without endoscopically proved mucosal ulcers group(II) included 15 (8 male &7 female)patients with cirrhosis and endoscopically proved mucosal ulcers. group(III) consisted of 20 (10 male&10 female) dyspeptic patients referred for upper GIT endoscopy were taken as control group. For all included patients detailed history,clinical examination, abdominal ultrasonagraphy, laboratory investigation and upper GI endoscopy were recorded.
The results of the present study showed that the frequency of peptic ulcer in patients with cirrhosis was more than that of non cirrhotic patients .
In this work there was no significant association between age, sex or smoking and presence of peptic ulcer in cirrhotic group.
The prevalence of H. pylori infection in cirrhotic patients was significantly lower than that in the control group .
further anaylasis of H.pylori infection in cirrhotic patients showed that H.pylori infection inversely co-related to degree of liver cirrhosis(Child-Pugh classification)
On the other hand the prevalence of H. pylori infection did not differ in patients with liver cirrhosis, whether peptic ulcer was present or not.
This study showed no statistically significant relation between Child-Pugh classification and peptic ulceration in cirrhotic group as the rate of gastro duodenal ulceration (46.7% in Child C patients and 26.7% in Child A patients).
This study shows an association between endoscopic evidence of portal hypertensive gastropathy and presence of peptic ulcer in cirrhotic patients, however it did not reach statistical significance.