الفهرس 
QT intervalOnly 14 pages are availabe for public view
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Abstract
Over the past decade, QTD has been used to
prognosticate patients with cardiovascular disease at risk for
ventricular tachyarrhythmias and sudden death. Few studies
have included patients with primary disorders that are noncardiac,
such as end-stage renal disease and diabetes.
This study was performed to asses the QTD in the
acute thrombotic stroke patients without evidence of heart
disease and to demonstrate the relationship between the site,
side of the stroke lesions and this QTD.
The study included 30 consecutive patients admitted
to the neurological critical care unit of Ain Shams
University Hospitals during the period from August 2008 to
March 2009, presented by acute thrombotic stroke for the
first time within 24 hours from the onset of symptoms and a
control group consisted of 30 patients.
All patients were subjected to a detailed history,
careful clinical examination, ECG in the first 24 hours and
after 72 hours of stroke incidence, QT dispersion
measurement and MRI.
Summary
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QT dispersion (QTD) and corrected QT dispersion
(QTcD) were manually measured from resting 12-lead
ECG.
Our study showed a significant increase of both QTD
and QTcD in the first 24 hours of the stroke incidence as
compared to those of the control group and to those of 72
hours after its incidence. Also, our study revealed
significant increase of both first day QTD and QTcD in
stroke lesions with insular involvement as compared to
those without insular involvement. However, there was no
significant difference regarding all the QTD measurements
(QT maximum, the QT minimum, QTD, QTc maximum,
QTc minimum and the QTcD) between the different sites of
the stroke lesions (cortical, subcortical and brainstem) as
detected by MRI. Likewise, the study showed no
significant differences between lesions in the two sides of
the brain (whether right or left) regarding all the QT interval
measurements.
According to the after mentioned data, we can
conclude that patients with acute thrombotic stroke without
evidence of heart disease (especially those with lesions
Summary
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involving the insula) may be exposed ventricular
tachyarrhythmias in their first day of illness as a result of the
increase in both QTD and QTcD.