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Abstract The recent advent of non-invasive methods for assessment of liver fibrosis allows serial assessment in all patients with hepatitis C to determine their response to treatment. Transient elastography measures tissue stiffness. It can measure liver sample size 100 times greater than a standard biopsy sample size, as liver biopsy size strongly affects the grading of chronic viral hepatitis. The aim of the study was to assess regression of hepatic fibrosis following combined treatment of chronic hepatitis C (genotype 4) among responders and non-responders using transient elastography. The study was carried out on 40 chronic HCV infected patients who received combined treatment. According to the sustained virological response patients were divided into two groups, 20 patients who achieved SVR and 20 patients who did not achieve SVR. Fibroscan was done before and after treatment for all patients. The results of the current study revealed that there was a significant decrease in Fibroscan value and METAVIR score among responders and non-responders after receiving treatment compared to pre-treatment values which would signify regression of liver fibrosis in both groups. |