الفهرس 
EpilepsyOnly 14 pages are availabe for public view
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Abstract
Idiopathic epilepsies are group of epilepsies that are genetically
determined have no structural or anatomic cause and usually begin early
in life. Neurologic examination, intelligence and imaging studies are
normal. EEG show only epileptiform abnormalities. In some idiopathic
epilepsy, the genetic substrate has been identified whereas in most, it
remains unknown (Benbadies, 2005).
Idiopathic epilepsies are a relatively new category of disorders
defined by strict clinical and electroencephalogram (EEG) features
proposed by the International League Against Epilepsy. The international
classification of epileptic syndromes has proposed strict clinical and EEG
criteria to individualize idiopathic epilepsies. Clinical experience has
shown that these criteria are not always fulfilled by every patient every
time and that idiopathic epilepsies represent a heterogeneous condition in
which many factors, such as age of onset, external factors, role of
medications, and sleep, interact. The precise clinical and EEG phenotype
of a single patient is often difficult to ascertain. Genetic studies have to
rely on the ILAE clinical and EEG criteria (Nordli, 2005).
The present work aimed to describe the epidemiologic profile of a
group of children and adolescents with idiopathic epilepsy through
studying the clinical characteristics of one hundred patients with the
disorder from those following up at The Neurology Clinic of Pediatrics
Benha university hospital.
Using the data collected from each patient from the history,
examination and investigations, the possible idiopathic epilepsy
syndromes of 100 consecutive patients were reached.
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Summary & Conclusion
The one hundred enrolled patients have been classified according to
the standards set for by the ILAE. Each case was subjected to detailed
history taking laying special stress on the types, etiology, age of onset of
seizures, family history of seizures or neurological illness, description of
the seizure disorder and medical treatment received, and through general
and neurological examination including developmental and cognitive
function assessment. Twelve(12%) percent were benign rolandic epilepsy,
6% were benign childhood epilepsy with occipital paroxysms, and 4%
were childhood absence epilepsy, 2% epilepsy with generalized tonic
clonic seizures on awakening. While 75% of patients were diagnosed as,
idiopathic generalized epilepsy not otherwise defined.
Upon enrollment, 78% of patients were on monotherapy, 14% were
on two drugs while 8% were on three drugs. Valproate and
Carbamazepine were the most commonly used medications as first and
second choice of treatment, and new AEDs were introduced starting from
the second trail, with increased frequency.
from our study, we can conclude that BCECTS is the commonest
epilepsy syndrome among the idiopathic specific syndromes; also, we can
note that a defined syndrome was not possible in nearly three quarters of
the cases (IGE with GTCS only) which paints the need for further
elaboration and studies on this large group. Inter-ictal wakes only EEG
study may result in loss of some helpful changes in sleep recordings, as
seen in a group of our patients with BCECTS.