الفهرس 
HOUSE DUST MITEOnly 14 pages are availabe for public view
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Abstract
A
sthma is the most summon chronic disease in childhood. There is marked increase in the prevalence of bronchial asthma world wide. The pathophysiology of bronchial asthma is complex. It involves air way inflammation (intermittent airway obstruction and bronchial hyper responsiveness.
Aim of work:
To assess the efficacy and safety of specific sublingual immunotherapy in treatment of asthmatic patients allergic to house dust mite.
Mechanisms of Action of immunotherapy:
Specific immunotherapy has been shown to modify T-cell responses to allergens in allergic individuals by increasing the ratio of Th1 to Th2 cytokines.
Subjects and methods:
Specific immunotherapy has been shown to modify T-cell responses to allergens in allergic individuals by increasing the ratio of Th1 to Th2 cytokines.
This study was conducted on 45 asthmatic children in pediatric pulmonary unit, Faculty of medicine Ain Shams University. Plus 15 health matched as a control group. They were divided into 3 groups:
Group I (experimental group): 30 asthmatic children was given sublingual immunotherapy.
Group II (placebo group): 15 asthmatic children was given placebo fluid (glucose 5%).
Group III (control group): 15 healthy matched children.
Group I and Group II were subjected to the following:
- Adequate medical history taking.
- Clinical examination.
- Skin prick test.
- Serum total IGE (ELISA) before vaccination and repeated after vaccination for group I and also before and after placebo for group II (the percentage from the highest normal for age) was the value used for data analysis.
- Pulmonary function test using spirometry before and after vaccination for group I and before and after placebo for group II.
- Absolute number of eosinophils in blood before and after vaccination for group I and before and after placebo for group II.
This study was done to discuss could sublingual immunotherapy of asthmatic children allergic to house dust mite be an effective treatment.
The patients were followed up for 4 months clinically and by pulmonary function test and laboratory by measuring serum immunoglobulin E and the absolute number of eosinophils in blood.
Results:
This study found that there is significant improvement of asthma severity in experimental group compared with placebo.
In this study regards levels of eosinophils and IGE before and after vaccination. There is highly significant relation of vaccinate group as regards IgE before and after vaccination and highly significant relation between vaccinated and placebo groups as regards eosinophils after vaccination.
As regards respiratory function test among experimental group there were highly significant relation between values of respiratory function test before and after vaccination.
While there were no significant relation for placebo group.