الفهرس 
Bronchial AsthmaOnly 14 pages are availabe for public view
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Abstract
The mortality rate in patients with asthma is still rising and has been partly attributed to the adverse effects of B2- agonists administered for asthma management.
Interest in electrolyte disturbance in asthma patients has so far focused on serum potassium especially linked to therapy with B2- agonists. Hypokalemia was the earliest electrolyte disturbance reported in acute asthma.
Hypokalemia, hypomagnesemia and hypocalcemia are well known causes of cardiac arrhythmia. In addition, hypophosphatemia can worsen respiratory failure in severely ill asthmatic patients.
Recently, hypomagnesaemia, hypocalcemia and hypophosphatemia have also been reported after administration of B2-agonists in normal subjects and in asthmatic patients as well.
Hence this study was done on forty adult patients with bronchial asthma, and ten adult healthy volunteers received inhaled B2-agonists for one week on daily maintenance dose as (control group). To study the prevalence of electrolyte disturbances in patients with stable and unstable bronchial asthma, and the influence of different drug therapy used to treat asthma comparing to normal subjects as control.
The asthmatic patients were divided according to the level of asthma control according to Global Initiative for Asthma 2008, into two groups:
Group (I):
Consists of twenty patients with chronic stable asthma,
Group (II):
Consists of twenty patients with acute asthmatic attack.
Diagnosis of bronchial asthma was confirmed by proper clinical history, chest X-ray, pulmonary function tests and ECG for all patients.
Details of drug therapy were obtained from patients of both groups. Patients with co-morbid illness like heart failure, renal diseases, diabetes mellitus and hypertension are excluded from the study.
All patients selected in the study were treated with inhaled β2-agonists administered as on need bases (Salbutamol), Inhalational steroids were administered as regular treatment (Beclomethasone) and oral theophylline therapy.
In this study we tried to identify relationship between the electrolyte disturbances and many parameters like age, sex, duration of therapy and identify the different correlations between the disturbed electrolytes.
In conclusion: The present study is a Prospective, hospital-based study of bronchial asthma patients at National center of chest diseases and asthma in Embaba.
It was found that:
• Hypomagnesemia and hypophosphatemia were the most common electrolyte abnormalities in patients with chronic, stable asthma.
• Hypomagnesemia and hypokalemia were the most common electrolyte abnormalities in patients with acute asthma.
• The incidence of electrolyte disturbances was higher among those patients with acute asthma as compared to those with chronic asthma, with the exception of hypophosphatemia which was reported more in chronic stable asthma.
• The effect of B2-agonists was not significantly different between those with normal or disturbed electrolytes. The use of therapy showed no effect on electrolytes level among the healthy population (control group).