الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
Many transplant centers consider a living donor transplant, tobe the optimal choice for the treatment of terminal uraemia. The immediate
risks and complications of donor nephrectomy have been studied and defined. Recent experimental work questions the long term safty of
donor nephrectomy,
The aim of this work was to evaluate the long term consequences of unilateral nephrectomy in a group of living related donors after variable periods of donation.
65 subjects (20 control and 45 donors) were investigated as regards serum creatinine, urine creatinine, creatinine clearance, complete urine analysis, 24 hours urinary protein excretion, clinical examination including blood pressure measurement and size of the kid-ney as measured by ultrasonography.
We found that there was a significant increase in serum creati-nine after nephrectomy in all donors, while urine creatinine and creatinine clearance decreased significantly. When compared with the control group, serum creatinine was significantly higher and creati-nine clearance was significantly lower in donors after nephrectomy than in control subjects. Urine analysis showed microscopic haematurea in only 7 donors. 24 hours urinary protein excretion showed no dif-ference from the values of control subjects. However, 5 cases showed gross proteinuria. Blood pressure showed no difference after nephrec-tomy from the values before nephrectomy or from that of control sub-jects. However, 3 cases showed diastolic hypertension.
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The changes in the investigated parameters showed no correlation with the time elapsed after donation except for the 24 hours urine protein which was significantly higher after 2 to 10 years of donation than after less than 2 years. Also, there was no correlation between the changes in the parameters investigated and the age of donors except for urine creatinine which was significantly lower in the group of donors whose ages are above 30 years.
from our observations we conclude that unilateral nephrectomy does not result in progressive deterioration in the remaining kidney
function and that the mild changes that occur after nephrectomy have no clinical importance.