الفهرس 
• Excimer Light Laser BasicsOnly 14 pages are availabe for public view
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Abstract
The excimer laser are a group of lasers that have found wide applications in a variety of medical fields including dermatology, cardiology, ophthalmology and orthopedics. The excimer laser is of particular interest to dermatology is the 308 nm xenon chloride.
The mechanism of action of excimer laser in Psoriasis is due to its apoptosis action. Also its apoptosis action is involved in treatment of Alopecia Areata, Mycosis Fungoides Oral Lichen Planus, Acne Vulgaris and Atopic Dermatitis. It was proved to be the strongest apoptosis inducer, while in vitiligo and hypopigmented lesions it causes an increase melanogenesis and melanocyte stimulating hormone.
Patients require 18-30 sessions for complete clearing. The intensity varies according to skin type. Determination of MED is very important as dose is calculated in terms of it. Exposure to UV light is early in the treatment cycle and then gradually increases over time.
It was subsequently demonstrated that these laser could precisely ablate surface of variety of tissues with almost no detectable thermal effect below ablated surface which was termed ”Cold Ablation”.
Excimer laser has a variety of applications in dermatology such as Psoriasis, Vitiligo, Alopecia Areata, Hypo-pigmented Lesions, Mycosis Fungoides, Oral lichen planus, Acne Vulgaris, Perioral Dermatitis and Atopic Dermatitis.
The dose of laser is calculated in terms of MED test, skin type should be determined. Fair skin takes a lesser dosage than dark skin. Patients attend twice weekly which is compatible to the patient.
Conclusion:
We conclude that excimer light laser is most effective and applicable in localized forms of psoriasis and vitiligo. It is also used in severe cases in other specific dermatological diseases such as apolecia areata, disorders of pigmentation, mycosis fungoides, oral lichen planus, acne vulgaris, atopic dermatitis and can not treat widely spreed dermatological diseases. It has short treatment sessions and is only focused on diseased skin with quick results thus well tolerated by patients.
Excimer light laser does not need anesthesia before treatment and patient does not need to avoid sun exposure after treatment, in comparison with other laser.
We concluded that 308nm excimer laser is by far better than topical therapy or oral therapy alone. In order to avoid drug to drug interaction and long term use side effects, so every dermatologist should think about the use of excimer light laser in treatment of dermatological diseases.