الفهرس | Only 14 pages are availabe for public view |
Abstract Myopia is a refractive disorder in which collimated light produces image focus in front of the retina when accommodation is relaxed. It has been classified into various manners like: according to etiology into axial and refractive, clinically into simple, nocturnal, degenerative, Induced , pseudo myopia and nearwork induced myopia, according to Age of onset into congenital , school, youth onset and adult onset myopia, according to degree into low, medium and high myopia . Degenerative or pathological myopia , a refractive error of more than -6 diopters associated with degenerative fundus changes, is a major cause of legal blindness. The main problem is the formation of Choroidal Neovascularization(CNV). These new blood vessels around the retina grow abnormally and leak fluid, causing the layers of the retina to separate, leading to its damage . Treatment of CNV includes Thermal laser , Photodynamic therapy and Surgical interventions which include removal of the choroidal neovascular membrane and macular translocation. These lines of treatment have been used in the attempt to treat myopic CNVs with varying success. As this abnormal growth of blood vessels is caused by Vascular Endothelial Growth Factor( VEGF), the scientists thought to use Anti VEGF as new line of treatment in such cases. There are many types of anti VEGF like: Pegaptanib sodium (Macugen) R ,Ranibizumab (Lucentis)R ,Bevacizumab (Avastin) R and other new modalities. Their ocular adverse events are rare. Different studies show the high efficacy of this new line of treatment in many cases of pathological myopia. |