الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Biomaterials used in regenerative medicine and tissue engineering are often designed
to act as scaffolds for tissue in three dimensions 3D and then safely dissolve once they have
performed their function, leaving the body to remodel the tissue to its natural form. Bioactive
glasses (BG) have been outstanding properties that allow them to be good candidates for bone
scaffolding materials.
Bioactive glasses are amorphous silica based materials that are biocompatible,
bioactive, osteoconductive, and even osteoinductive. The aim of this study is to prepare and
characterize a sol-gel derived 3D calcium silicate BG system (70 SiO2–30CaO mol%), that
exhibit suitable properties to be used for biomedical and tissue engineering applications. The
prepared scaffolds were characterized with scanning electron microscopy (SEM), light
microscopy, mercury porosimetry. The mechanical testing of the scaffold has been done by
dynamic mechanical analyzer (DMA). The in vitro bioactivity of the scaffold was tested by
soaking the prepared scaffolds in phosphate buffered saline. The formation of the
hydroxycarbonate apatite layer (HCA) was monitored by energy dispersive x-ray (EDX),
fourier transform infrared (FTIR) spectroscopy, x-ray diffraction (XRD). The initial response
of rabbit bone marrow derived mesenchymal stem cells cultured onto the prepared scaffolds
was monitored by SEM. Finally, the in vivo biocompatibility as well as angiogenic activity of
the material was evaluated histologically in white New Zealand rabbit models.