الفهرس 
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Abstract
Part I deals with an introduction to chemometric methods in phaimaceutical analysis used in this thesis. These methods are:
- Derivative ratio methods (First and second derivative ratios)
- Multivariate methods
Multiple Linear Regression (MLR) methods
• Classical Least Squares (CLS) or K-mafrix).
• Inverse Least Squares (ILS) or (P-matrix).
• Q-matrix
Factor-based methods
• Principal Component Regression (PCR, PCA or Factor Analysis)
• Partial Least Squares (PLS)
Part II deals with the spectrophotometric determination of omeprazole, lansoprazole and pantoprazole in presence of their acid induced degradation products. The studied methods are the derivative ratio methods (first and second) and the multivariate methods (CLS, Q-matrix, PCR and PLS) using the absorbance ratio and the absorbance data.
The methods were validated and applied to the determination of the
three investigated drugs in laboratory prepared mixtures with their acid
induced degradation products and in their pharmaceutical preparations.
The derivative ratio methods (first and second) at the selected analytical wavelengths determine the three investigated drugs with high degree of accuracy and precision in laboratory prepared mixtures with their acid induced degradation products and in their pharmaceutical preparations.