الفهرس 
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Abstract
Copper is an essential micro-nutrient element that occurs in rock, soil, water,
sediment, air, plants and animal tissues. The concentration of copper in river and lakes
has dramatically increased as a result of discharge of effluents from farms, the production
of antifouling paints and copper mining, and therefore, has adversely affected aquatic life.
Our studies were conducted to evaluate the incidence of heavy metal pollution in
both water and tissues of catfish, Clarias lazera. from Ismailia Canal.
Fifty water and catfish, Clarias lazera, samples were collected from five different
localities of Ismalia Canal (Mostord, Abou-zabal, Belbeis, El-Abbasa and Ismailia
Governorate). Ten samples were collected from each locality for analysis of copper.
mercury, lead and cadmium. The mercury surface water level was found to be above the
maximum permissible limit at Mostord and Abou-Zabal. The concentrations of mercury
and lead in muscle tissue exceeded the perrnisxible limit at Mostord and Abou-Zabal
only.
The 96 hr LC value of copper as copper sulfate in Juvenile channel catfish ’)0
lctalarus punctatus. was estimated. The effects of acute and subchronic copper tox icity
on the hematological picture. serum biochemical parameters, pathological studies. liver
metallothionein concentration and rnacrophages chemotaxis have bccen investigated in
channel catfish, lctalarus punctatus. Also. the effects of subchronic copper toxicity 011
reproduction hormones of mature male and female channel catfish. Ictalarus punctatus.
were recorded.
The 06 hr LlSO value of copper a.-; copper sulfatc in juvcuile channel catfish.
lctalarus punctatus. was 0.2 ppm at 23”C. total hardness 55 mg/}. and dissolved oxygen 8.3mg/L.