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Abstract In this study examine bee venom as therapeutic agent in laboratory animals to determine therapeutic dose and also study safety and efficacy of this therapeutic dose by collecting serum and blood samples from the injected rabbits to evaluate hematological, biochemical, and immunological changes in the blood and serum. The effect on clinical and pathological picture of the injected rabbits was also determined. Also bee venom was studied in CCl4 induced hepatitis in rats to approve possibility to use it as therapy for chronic liver diseases. Injection of animal venom (bee venom) for treatment of deleterious effects in horses immunized for preparation of cobra antivenom in both newly immunized horses and previously immunized horses for 5 years. Serum and blood samples were collected from the two groups of horses to evaluate hematological, biochemical, and immunological changes in the blood and serum. The effect on clinical and POSt mortum picture of the horses were also determined. We noticed that there were some improvement in hematological, biochemical and immunological parameters in horses treated with bee venom. According to these results precise consideration should be undertaken while preparation of the antivenin by application of bee venom treatment schedule for up to 4 months to avoid the deleterious effects on the cobra-immunized horses for long period. |