الفهرس 
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Abstract
Aflatoxins have been implicated in affecting male reproductive health in human and animals. This investigation was conducted to evaluate the reproductive toxic effects of aflatoxins in male rabbits and to contribute additional insight into links between dietary aflatoxins and the risk of adverse male reproductive events induced by apoptosis and oxidative DNA damage. A total number of thirty five adult New Zealand male rabbits were randomly allocated into 5 groups receiving graded levels of aflatoxins at 0, 20, 250, 500” and 1000 ppb/ kg diet for 75 days. Parameters of routine semen analysis showed progressive decline in ejaculate volume, mass motility, individual progressive motility, live sperm and sperm acrosomal integrity, and increases in reaction time and sperm abnormalities in all aflatoxin treated groups. Aflatoxins caused decreasing in plasma testosterone levels in treated groups. Aflatoxins caused testicular alterations including mild testicular degeneration to complete atrophy of seminefrous tubules and loss of all stages of spermiogenesis, peritubular edema, presence of intraluminal multinucleated spermatid giant cells. The histopathological changes of different organs were discussed. Aflatoxicosis was characterized by induction of apoptosis and DNA fragmentation. Aflatoxins caused reduction in antioxidant and increase in oxidative biomarkers indicating oxidative stress. In conclusion the toxic reproductive effect of aflatoxins included testicular damage with subsequent reduction in plasma testosterone; oxidative stress, apoptosis, and DNA fragmentation of sperm provide insights into reproductive toxicity of aflatoxins.