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Abstract The aim of this thesis was to study the incidence and mortality rates in diarrhoeic rabbits suffering from E. coli infection. Correlation between biotyping and serotyping of E. coli isolates revealed the following: O8/1-; O20/1+; O26/2+; O15/3-; 0153/5+ and O128/8+. Virulence attribute confirmed that these strains were belonging to enleropathogenic E. coli. The comparative protective capacity of the ultrasonicated, irradiated, heat inactivated, formalinized inactivated as well as attenuated-irradiated vaccines was elucidated using challenge test, local IgA antibody response as well as immunohistopathological response. Results indicated that the ultrasonicated vaccine was the best vaccine for protective against E. coli infection in rabbits. |