الفهرس 
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Abstract
The systemic inflammatory response syndrome can be self-limited or can progress
to severe sepsis and septic shock. Persons with a weakened immune system are most
likely to develop sepsis, but the detrimental processes that may ultimately lead to the
death of the patient are mostly caused by an exaggerated, systemic response to an
infection.
Infections are fought in the body by both cellular defenses, including monocytes,
macrophages, and neutrophils, and humoral defenses incorporating antibodies and the
complement pathways.
EGDT can be summarized in the following points :-
1. Early recognition and management of severe sepsis/septic shock optimizes outcome .
2. Continuous monitoring of vital signs , pulseoximetry , and urine output and initial
laboratory testing
3. Simultaneously , a source of infection should be sought
4. Empiric antibiotics should be initiated as soon as possible .