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Abstract Haemolytic disease of the newborn is adisease which ste.rts in utero and causes jaundice and enlar- gement of the liver and spleen of the foe’tu.s,the sever- ity of the disease ranges from mild to· form with mental retardation brain damage, kernicterus or still birth (Potter, 1964). ABo hemolytic disease of the newborn caused by materno-fetal incompatabili ty constitutes about two thirds of cases of HDNB but is also usually milder Md consequently more difficult to diagnose although, (ABo incompate,bili ty occurs in about 15% - 20% of pre- gnancies, HDNB occurs in only 20% of babies atrisk (Anderson et-al., 1963). Tetanus toxoid vaccine increase the ABo, incompa- tabili ty haemolytio diseases in newlyborn when given to pregnant mother (Oski et al., 1982 , Gupte & Bhatia,1980). This work comprise 348 cases devided into two groups. The first group: 198 vaccinated pregnant mothers in the childbearing period and their newly born infants they vaccinated by adsorbed type of tet~B_’ toqla during pre- gnancy. |