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Abstract
Deep vein thrombosis (DVT) is a popular and serious disease.It can lead to serious complication; the most fatal of them is pulmonary embolism (PE).The cornerstone of proper management of DVT is early diagnosis & prompt treatment. The diagnosis of DVT is not an easy process because most of clinical manifestations are not conclusive and shared with other diagnoses. The development of Wells scoring system improved a lot the ability of specialists in diagnosis of DVT.The diagnosis of DVT depends a lot on objective tests; the standard of them is duplex study of deep venous system. Duplex study equals the accuracy of venography but less invasive.Laboratory improvement in the study of coagulation system has been discovered unique product resulting from action of plasmin on cross-linked fibrin contained in the thrombus. Its detection depends upon monoclonal antibodies to epitopes on surface of D- dimer