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Abstract
Endothelin-I (ET-I) is a vasoconstrictive peptide. produced by
vascular endothelium and acts in a paracrine manner on adjacent vascular
smooth muscle thus continuously regulating the peripheral vascular
resistance.
There are discordant data on the impact of a hemodialysis session in
plasma ET -I level and also contradictory reports on circulating ET- I
levels in the presence of elevated blood pressure that frequently
accompanies ESRF.
The aim of this study is to estimate the plasma level of ET-I in
children with chronic Renal Failure (CRF) both on conservative!
management and those on hemodialysis and also to compare the effect of
ultrafiltration combined with hemodialysis and the effect of isovolumic
dialysis on the time course of circulating ET-I in hypertensive and
normotensive patients on maintenance hemodialysis.
40 children was enrolled in this study. They were divided into -+
groups. group (A) includes 10 children CRF on conservative
management. group (B) includes 10 hypertensive patients with ESRF on
regular hemodialysis. group (C) includes 10 normotensive patients with
ESRF on regular hemodialysis and group (D) (control group) includes 10
children proved clinically and laboratory to be healthy. All the dialysis
patients were on regular hemodialysis 3 times weekly with average
duration of dialysis session 3 hours. In this study, the dialysis session was
designed into 2 phases:
Phase I: The 1 SI 2 hours where ultrafiltration combined with
hemodialysis is done.
Phase 11: The last hour in which the isovolumic dialysis was done.