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Abstract
Cytochrome P450 1A2 (CYP1A2) is involved in the metabolism of many medications as well as in the activation of many pro-carcinogens. Modulations of CYP1A2 enzyme activity and inducibility are associated with adverse drug reactions besides increased risks of several malignancies. Similarly, CYP1A2 is affected by several factors which are involved in the pathogenesis of depression such as psychological stress, increased inflammatory cytokines and increased glucocorticoids.