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Abstract 3-mercapto-1-morpholin-4-yl-5.6.7.8-tetrahydroisoquinoline-4-carbonitrile(II) was synthesized by the reaction of 3-amino-1-thioxo-5.6.7.8-tetrahydro-1H-isothichromene-4-carbo nitrile (I) with morpholine. Reaction of isoquinoline derivative II with a-halogenated carbonyl compounds in ethanol in the presence of sodium acetate afforded the alkylated compounds IIIa-j. |