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Abstract
Most of the vascular disorders of the Liver are rare with the exception of portal vein thrombosis in patients with cirrhosis
In cirrhotic patients with PVT, compared with those without PVT, however, molecular testing, however, molecular testing shows an increased prevalence of the factor V Leiden, and prothrombin gene mutations, the latter being particularly common
Endoscopic therapy of esophageal varices has been suggested to precipitate the development of PVT patients with compansted cirrhosis and acute or chronic PVT there are limited data on the utility of screening for an underlying prothrombotic condition,and on the benefits of anticoagulation the absences of robut data Recommendations for or against routine anticoagulation cannot be made decision will to be made on case by case basis
The decision to use prophylactic therapy should take into account the predominant underlying physiology, the history of bleeding and the risk-benefit of the procedure as well as the likelihood that rescue therapy would be available should bleeding occur The overall therapeutic strategy in approaching bleeding risk can be broadly divided into prophylactic or preventive therapy versus the wait and see approach of rescue therapy (i.e., intervention in the setting of active bleeding). The inherent clinical problem in either approach but especially with prophylactic therapy is the inadequacy of conventional laboratory tests to measure risk rather than an absence of risk.