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Abstract
The present study has been initiated to evaluate the radioprotective effect of septilin against whole body gamma
radiation and identifying the mechanism whereby septilin extract could protect against radiation toxicity.
Irradiation induced significant increase in the serum enzymes of liver ASAT, ALAT, ALP, GGT activities and total bilirubin level when rats exposed to both gamma irradiation doses while direct bilirubin level rise when rats exposed to 6Gy gamma irradiation only. There was a significant increase
in total cholesterol, triglycerides and LDL cholesterol with significant decrease in HDL cholesterol. Besides, it produced high levels of liver malondialdehyde, nitric oxide while serum nitric oxide rise when rats exposed to 6Gy gamma irradiation
only with significant decrease in total glutathione in liver and liver superoxide dismutase activity. Irradiation induced significant decrease in WBCs, RBCs, Hb, PCV, platelets count and blood indices.
Septilin manifested good amelioration in the radiationinduced changes in the studied parameters and histopathological changes.
Hence, it could be concluded that septilin plays a beneficial radioprotective role against radiation hazard in male albino rats.