الفهرس 
Psoriasis
Patients and MethodsOnly 14 pages are availabe for public view
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Abstract
Psoriasis is an immune-mediated, genetic papulosquamus disease of
the skin, mucous membranes, nails and joints. It is characterized by
cycles of remission and exacerbation. It is a multifactorial disorder
caused by the concerted action of multiple disease genes in a single
individual triggered by environmental factors. Psoriasis vulgaris is the
most prevalent T-lymphocyte–mediated inflammatory disease in humans,
which is characterized by hyperproliferation and poor differentiation of
epidermal KCs. It is hypothesized that pathological inflammation results
from activation of the type 1 T-cell axis in skin lesions.
NB-UVB phototherapy emitting light in the 311 nm to 313 nm spectra
has been used successfully for the treatment of psoriasis. UVB alters an
immunological function. NB-UVB causes greater depletion of T-cells in
psoriatic tissue and establish direct cytotoxic actions of UVB on T-cells
infiltrating skin lesions.
SPs have an essential role in the first line defense of skin diseases
including psoriasis. SP-A plays an important role in host defense. While,
SP-B molecules integrated in the phospholipids and important for the
ability of surfactant to reduce surface tension.
The study was done on 20 psoriatic patients and their age ranged from
20-65 years. They were selected from the outpatient clinic of
Dermatology, Venereology and Andrology department, Faculty of
Medicine, Menoufyia University. All patients were subjected to complete
history taking, clinical and dermatological examinations. They were
treated with NB-UVB with duration of treatment ranged from 16-24
weeks with a mean of duration 18.05 weeks.