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Abstract
Zinc is one of the essential trace elements. It is a widely distributed element in human body.
Zinc deficiency can readily induce programmed cell death or apoptosis.
Therefore, this study was designed to clarify possible effects of zinc deficiency and toxicity on hepatic and renal functions. Moreover, to estimate the potential role of zinc as protective element against oxidative stress in case of acetaminophen induced hepatotoxicity and nephrotoxicity in rat.
This study was carried out on 56 adult male white albino rats which were divided into 7 equal groups each group contains 8 animals.
This study investigated parameter of liver functions including liver enzymes(serum ALT, AST) and direct bilirubin as well as parameter of kidney functions including BUN, serum creatinine and uric acid. Over and above histopathology was done in a trial to provide evidence to the serum changes.
As regarding the liver, zinc deficiency produced a significant increase in serum levels of ALT, AST and direct bilirubin.
Concerning the kidney, the result of this work revealed that zinc deficiency resulted in significantly elevated levels of serum BUN, creatinine and uric acid.
In our study, the excess dose of zinc injection led to marked elevation of liver enzymes (ALT and AST) together with strictly increased direct bilirubin.
Also, in the kidney there was a significant increase in BUN, serum creatinine and uric acid.
A single oral toxic dose of acetaminophen was followed by eight folds increase in serum ALT and six folds increase in serum AST. But, zinc treatment markedly suppressed the elevated liver enzymes.
In addition, acetaminophen induced nephrotoxicity was manifested by significantly high levels of BUN, serum ceratinine and increased uric acid. But, after zinc treatment, partial protection was achieved.