الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Exposure of the body to ionizing radiation produces reactive oxygen species (ROS) which damage proteins, lipids and nucleic acids. Because of the lipid component in the cell membrane, lipid peroxidation is reported to be susceptible to radiation damage. So the present study was performed to detect the role of Foeniculum vulgare Mill, essential oil (250 mg/kg b.wt.) to overcome the hazards of ionizing radiation. The parameters studied in the current work were serum AST, ALT, ALP, total bilirubin, proteins profile (total protein, albumin, globulin, and A/G ratio), cholesterol, triglyceride as well as levels of urea, creatinine and testosterone in serum. Liver and kidney glutathione (GSH) content; lipid peroxidation (TBARS) and metallothioneins (MTs) levels were also investigated. In addition, levels of some trace elements (Fe, Cu, p5n, Ca, Mg, Mn and Se) in liver, kidney, spleen and testis tissues were also estimated. Male Swiess albino rats (32) were used, weighing 120-150g, divided into 4 groups, each consists of 8 rats: group 1 was normal control group (non-irradiated), group 2 consisted of rats subjected to a single dose of whole body gamma irradiation (6.5 Gy), and sacrificed after 7 days of irradiation, group 3 received Foeniculum vulgare Mill, essential oil (FEO) (250 mg/kg b.wt) for 28 successive days by intra-gastric gavage and group 4 received treatment JFEO for 21 days, then was exposed to gamma-radiation (6.5Gy), followed by treatment with FEO 7days later to be 28 days as group 3. Sacrifice of all animals was performed at the end of the experiment and blood, liver, kidney, spleen and testis were obtained for determination of different biochemical parameters. The results of the present study can be summarized as follows: 1- Rats exposed to gamma radiation exhibited a profound elevation of aspartate amontransferase (AST), alkaline phosphatase, bilirubin, urea and creatinine levels, lipid (cholesterol, triglyceride) abnormalities and an increase in lipid peroxidation and metallothioneins level. Noticeable DROP in liver and kidney glutathione content, serum total protein, albumin and testosterone levels were also recorded. Tissue organs displayed some changes in trace element concentrations. 2- Rats treated with fennel oil before and after whole body gamma irradiation showed significant modulation in transaminases, alkaline phosphatase, bilirubin, urea and creatinine, lipids and noticeable improvement in the activity of antioxidants (glutathione, metallothioneins) and protein profile (total protein, albumin). Fennel oil was also effective in minimizing the radiation-induced increase in lipid peroxidation as well as trace elements alteration in some tissue organs comparing: with irradiate] control rats. It could be concluded that Foeniculum vulgare Mill, essential oil exerts a beneficial protective potentials against many radiation-induced biochemical perturbations and disturbed oxidative stress markers.