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Abstract
The induction of labor is frequently indicated for a variety of obstetric medical, and social conditions (Cheng et al., 2008). Approximately 22% of women undergo induction of labor each year in the United States martin et al., 2009). The condition of the cervix is important to the success of labor induction, (Bujold et al., 2004). The available methods for promoting cervix ripening and induction of labor include stripping sweeping of the membranes, osmotic dilator, mechanical dilators, estrogens Prostaglandins, relaxin, mifeprestone (RU486), corticosteroids Pre-labor rupture of the membranes at term, nipple stimulation, sexual intercourse acupuncture, and Castor, oil, bath and or enema for cervical priming and induction labor (Kelly et al., 2001; Gülmezoglu et al., 2006;Chen et al 2008) stated that Prostaglandin analogs and nitric oxide-donors have been shown to be useful in cervical ripening before first or second trimester surgical abortion or labor induction at term. This process seems to be induced by the migration of inflammatory cells into the cervix and by the release of cytokines and proteases and a resulting disintegration of cervical connective tissue. Prostaglandins act by attracting inflammatory cells by chemotaxis and initiate and maintain a local inflammatory reaction. Unlike prostaglandins, which stimulate myometrial contractions,
nitrates only seem to induce cervical softening, but do not lead to a
contraction induced dilation of the cervix. (Vaisanen–Tommiska et al.,
2005) Vaisanen–Tommiska et al., suggest a misoprostol induction of
cervical nitric oxide release in pregnant women thereby confirming a
physiological link of prostaglandin and nitric oxide effect on cervical
tissue.