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Abstract
The concept of limb-sparing surgery for bone
sarcomas has gradually evolved over the past 25 years. The last two decades have witnessed a dramatic change in the management of musculoskeletal neoplasia. Better
understanding of the biology of bone tumors, the advent of adjuvant and neoadjuvant chemotherapy, and advances in imaging technology, in addition to the refinement in techniques of reconstructive surgery, have all made limbsparing surgery possible. Before this, all high-grade bone sarcomas were treated by amputation.This study included 30 patients (14 males and 16 females) with primary malignant neoplasms around the
knee Their age ranged between 11 to 53 years. It was done and or followed at Elmenoufia University Hospital and Ain Shams University Hospitals between 2007 and 2010.In order to treat tumor successfully, an accurate histological diagnosis is a primary requisite. Biopsy is akey step in the diagnosis of a musculoskeletal tumor. A biopsy may be an open procedure, incisional or excisional of the tumor or a closed procedure performed with needle or trephines. The biopsy should only be performed at the conclusion of staging According to the histopathological diagnosis of the patients we had; 20 patients with osteosarcoma, 2 patients with chondrosarcoma, and 5 patients with malignant giant cell tumor, one case lymphoma and 2 cases MFH The patients who proved to have chemo-sensitive tumors (20 patients) were referred to the Oncology and Nuclear Medicine Department at Elmenoufia University Hospital or Ain Shams University Hospital, to receive their appropriate induction adjuvant and neoadjuvant chemotherapy protocols aiming at local control of the tumor and systemic control of metastatic disease to increase the disease-free and overall patients’ survival rates.