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Abstract
Osteoporosis has been described extensively in adult thalassemic patient. In this study, we measured the bone mineral density (BMD) of 40 thalassemic patients (14 males (40%) and 26 females (60%) with an age of 22-45 years (mean 31.02±6.23 years) attending in the hematology clinic at Ain Shams University Hospital and the
Therapeutic Unit of the Egyptian Company for Blood Transfusion Services in VACSERA for repeated blood transfusion and follow up.
The aim of our study was to correlate the biochemical and mineral changes with the bone density changes of
thalassemic patients through:
(1) Full history taking stressing on age at diagnosis, frequency of blood transfusion, administration of iron
chelators, patient compliance and history of splenectomy.
(2) Estimation of serum zinc, calcium, phosphorus, magnesium, total alkaline phosphatase, serum iron and serum ferritin They were divided into three groups according to bone mineral density of the spine and the left femur.Our study confirmed that patient with thalassemia have a lower bone mineral density parameters. Regarding
to DEXA results, most of the patients’ BMD were affected (85%) with 50% of them having osteoporosis and (35%)
having osteopenia.
Also there was a highly significant difference between the degree of BMD affection in the left femur and the level of serum zinc in plasma being lower significantly in osteoporotic patients.