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Abstract Opioids Nowadays, Are Considered As A Conerstone In Management Of Chronic Pain Either Malignant Or Non Malignant Pain. Also , Opioid Usage In Pain Management Is Still A Growing Medical Field Especially With The Rapid Progaession In The Field Of Opioid Receptors Molecular Biology. The Oral Rout Of Intake Is The Most Preferable Rout Of opioids Admensteration. Opioid Analgesics Should Be Given By The Clock. Meaning At Fixed Time Intervals. If Beak-Through Pain Is Occurred It May Be Managed By The Means Of Rapid Acting Opioids As Oral Transmucosal Fentany Citrate (OTFC) Pulmonary Delivery System For Morphine And Fentany, Effervescent Buccal Fentany Tablets. Failure Of One Opioid In Management Of Patient’s Complaint Dose Not Mean Failure Of All Opiods, As We Have To Try Other Opioid Options: So,Pain clinician Must Be Expert In The Field Of Opioid Rotation And Equivalent Doses Calculation. |