الفهرس 
scope of investigation
general introducationOnly 14 pages are availabe for public view
 |  | from | 16 |  |  |
| | | from | 16 | | |
Abstract
This thesis oomprizes general introduotion, review of literature) experimental seotion, results and discussion. The main topic of the thesis concerns the analysis of some basio amines utilizing nonaqueous acid-base titration. The
main solvent of the present investigation is MIBK which possesses many of the desired qualities of a wide range titration medium. Also mixtures of,MIBK-other solvents (benzene, p-dioxane. Iaethanol or glacial aoetio aoid)in the ratio of (80:20) were
used.
In the present i~vestigation the basic amines analysed havs different strengths and different amino groups, some of them are primary aromatic amines as benzY’lamine, benzocaine, seoondary amine as diethylamine and tertiary amines as tri-
ethy’lamine I py ridine, 2-amino pjT’r idine t 4-amino ant ipy’r ine I
3-methyl-l-phen:rlpyrazol-5-one, ant ipy’rine t ami do py’rine,
dipy-rone , hexamine, brucine and caffeine.
Primary amlnes react with ketones forming Schiff bases
therefore tri8~s have been made to overoome this problem by
indirect titration.
Beoause ll/IIBK has differentiating property’” mixtures of amines (aliphatio and aromatic) were suocessfully’ resoluted in it and a good differentiating curves have been obtained for their potentiometric titration.
It was interesting to get relationship between halffneutralization potential (~p) of nonpharmaceutlcal bases in 1ITBK and its pKbfS in water. Colleotive titration ourves and tables oonta1ning percentage recovery’, ~p and mv break per ml of the atudied compounds are listed in detail in the thesis.
The pharmaceutical bases chosen are different in their
strength. some of them ar& strong enough to be titrated in MIBK and in MIill{-other solvents. Some of the chosen bases as hexamine, dipyrone are insoluble in MIBK but this problem was
..
overcome by’ using the binary’ solvent systems, MIBK-benzene,
M.Il3K-p-dioxane, MIl3K-metho.nol or MIEK-glaciaJ. acetic acid. Othel” bases are slightly’ weak to be directly ti’1;rated, so
the addition of neutral salts, as mCl”curio aoetate, facilitated their determination that was demonstrated bY’ the enhancement in the potential break IJlJ.d in the decrease in the Ermp values of the tested bases. This decrease in ~p accompo.ny’ing the enhanoing in end-point inflections was clear in the case where benzene and p-dioxane were the additive solvent, methanol and glaoial acetic aoid showed the least effect.
Generally the present investigation leuds to the presumpttion that the strength of the investigated non-pharmaceutieul
I
bases in MIBK and ita binary’ mixturo doereases in the following
order: DEA. TEA, benzylo.minc, 2-aminopyridine, 4pY’l’ino, pyridino.
Tho strongth of phc...rmaccutic>ci omincs in the investigutod solvents may also bo arranged L~ the following decreasing
orders brucine, hexamine, amidopyrine, antlpy’rine, dipy’rone, benzooaine t caffeine.