الملخص العربي
ACKNOWLEDGMENT
Table of contents
List of Abbreviations
List offigures
List of Tables
Introduction
Aim of the work
Review oflitertitlire
The Hallmarks of Cancer
Insensitivity to Antigrowth Signals
Evading Apoptosis
Limittess Replicative Potential
Sustained Angiogenesis
Tissueinvasion and Metastasis
Genome Instability
Epidemiology and Etiology of Bladder CancerEpidemiology and Etiology of Bladder Cancer
Pathological types of Bladder Cancer
Grades of Bladder Caneer
Stages of Bladder Cancer
Genetic and epigenetic aspect of bladder cancer
Genetic polymorphism
Genetic alteration
Epigenetic alteration
Molecular pathways in bladder cancer
Initiation of carcinogenesis-oncogenes and ehromosomal alterations
Tumor suppressor geines
Retinoblastoma TSG
p53 TSg Combination of Rb anD p53 TSGS
p21 TSG
Deciphering cell cycle regulation in TCC
The Tissue Matrix System
Nuclear matrix
General features of the NM structure in tumors
Adhesion Molecules
The cell-cell adhesion molecule E cadherin
Introduction to E-eadherin
Basic structure of the E-cadherin protein and its encoding gene and transcript
E-cadherin-catenin-cytoskeleton interactions
Dysregulation of the E-cadherin gene in cancer
Cathepsin D
Basic information
Role of cath-D in cancer progression and metastasis
Complex role of cath-D in apoptosis
Proteinuria and bladder cancer
Patients and Methods
Results
Discussion
Summary and Conclusions
References
الفهرس 
