الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Coronary artery disease is the largest single cause of death in the world.
In developed countries more than 25%of all deaths in persons older than 35 years are due to CAD. More than one half of acute myocardial infarctions occur without previous history or symptoms of CAD. These figures are approaching to be equal in developing countries in last few years due to similarities of life style and food habits. Aortic valve sclerosis is a common finding on echocardiography; in population-based studies, aortic sclerosis is present in about 25% of adults over 65 years of age ( 2-4). Aortic sclerosis was defined as increased echogenicity, thickening, or calcification of the leaflets. There were significant variations in echogenicity, thickening, or calcification of the valve leaflets on echocardiography, and it was found reasonable to employ these features to construct a qualitative grading system. The severity of aortic sclerosis was graded on a scale of 0 to 3. Aortic valve sclerosis is associated with many of the same risk factors as coronary artery disease (CAD). Clinical factors associated with aortic sclerosis include age, male gender, hypertension, elevated serum levels of lipoprotein (a) and low-density lipoprotein (LDL), smoking, and diabetes (3, 5-7) The presence of aortic sclerosis is associated with adverse clinical outcomes, e.g. myocardial infarction, heart failure and stroke (14) and this association is not specific to the aortic valve with adverse outcomes also associated with mitral annular calcification at a similar risk level (15-17) The study was designed to correlate between the presence and severity of aortic valve sclerosis and mitral annular calcification, on one hand, and the severity of coronary artery disease on coronary angiography, and the relation of these lesions to serum LDL, CRP & Calcium.
The study was carried out on 100 IHD patients who were diagnosed to have coronary heart disease by coronary angiography and then underwent echocardiography. The study excluded all subjects with aortic stenosis (peak velocity 2 m/s.), prosthetic aortic valves, age below18 years, chronic steroid use or immunosuppressive therapy, chronic inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, systemic lupus erethematosis.