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Abstract
This study was done to evaluate the efficacy of oral anticoagulants versus heparin therapy in the management of
Antiphospholipid Antibody Syndrome (APAS) during pregnancy.
Eighty patients with the diagnosis of APAS were enrolled in this study. Treatment was started once the diagnosis
of pregnancy was established.
All patients was advised to have small dose of aspirin 75mg once daily since start of pregnancy and 5 mg folic acid
daily once pregnancy diagnosed either by pregnancy test and is positive pregnancy test in urine or serum or diagnosed by ultrasonography.
The patients were randomized into two groups: Group I received heparin (5000 IU subcutaneously every 12 hours) and
a daily dose of 75mg aspirin. On the other hand, Group II received oral anticoagulant therapy (keeping the INR 1.5-2)and a daily dose of 75mg aspirin when patient reached successfully 16th week’s gestation or when pregnancy
disturbance occurred the study ended and the patient advice to continue the medication until 37 weeks gestation.
All patents were followed up throughout pregnancy by blood samples for PT, PIT, CBC ,together with US, Doppler,
tests for fetal wellbeing, compliance of the patients, duration of pregnancy and the development of complications whether due to APAS or adverse reactions to the drugs used.