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Abstract
The study was carried out on 32 adult female albino rats as two groups control 8 rats were injected IM only with the vehicle every 5 days , experimental 24 rats were divided into two subgroups each one of 12 rats. (E1):receiving 1.5 mg/kg B.W of Mesigyna every 5 days for 6 times while (E2) receiving Mesigyna as E1 the animals were left for 15 days without any treatment after the end of experiment, animals sacrifed , two uterine horns were excised and processed to prepare 5 mm paraffin sections. Sections were subjected to both histological and immunohistochemical techniques .
E1 group showed luminal epitelial proliferation , pseudostratification, tufting, hyperplasia and increase foldings of the endometrial mucosa reduction of endometrial thicknes and collagen fiber amount signficant increase in gland sizes)p<0.01, the mean perimeter of the glands was 30.06+2.6, and stromal cells p>0.05, the mean number of stromal cells was 50.33+ 2.87. increase opticaldensity of of glycogen matrials in the uterus, decrease in number of positive PR immunostained nuclei of surface, glandular epithelium , stroma cells, decrease in the mean optical density of the positive PR immunostained nuclei of surface glahdular epithelium stromal cells. E2 group showed changes similar to that of E1 group expect decrease in endometrial thickness, decrease in the optical density of PAS positive , material in glandular epithelium increase in optical density of PAS materials in myometrium decrease in number of positive PR immunostained nuclei in surface epithelium, decrease in the optical density of positive PR immunostained nuclei of stromal cells, glandular epithelium.