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Abstract
To study chromosomal abnormalities in patients with myelodysplastic syndrome and different methods of cytogentic and molecular analysis available for detection of these abnormalities. Myelodysplastic syndrome (MDS) represents a heterogeneous group of clonal disorders of pluripotent hematopoitic stem cells characterized by hyper cellular bone marrow, with dysplastic changes in multiple cell lineages and ineffective hematopoisis leading to peripheral blood cytopenia.
Myelodysplastic syndrome can be classified as primary or secondary. The exact mechanism that contributes to the development of primary MDS is unknown. Secondary MDS may develop in individuals who have been exposed to excess ionizing radiation or cancer chemotherapy, some congenital diseases such as Down syndrome and Fanconi anemia are also associated with MDS development.