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Abstract
Wound healing is a complex biological process, comprised of a series of a sequential events aiming to repair injured tissue. The role of the immune system in this process is not only to recognise and combat the newly presented antigens at the site of injury, but also to participate in the debridement of the damaged area and to contribute to the process
of healing. Skin scars are the normal and inevitable outcome of mammalian tissue repair Skin scarring covers a wide spectrum of clinical phenotypes from normal fine lines to abnormal widespread, keloid, atrophic, hypertrophic and surgical scars and scar contractures. Abnormal scars can cause unpleasant symptoms and be aesthetically distressing, disfiguring, and psychosocially and functionally disabling. Keloids are benign skin tumours occurring during wound healing in genetically predisposed patients. They are characterised by an abnormal deposition of ECM components, in particular collagen. There is evidence that TGF-β is involved in keloid formation. TGF-β1 and β2 isoforms have been proposed to be significant in the pathogenesis of keloid. However, hypertrophic scar is due to excessive tension on the wound or abnormal apoptosis. Mast cells are involved in physiological processes and maintenance of homeostasis, in addition to playing a critical role in host defense. Mast cells exert their biological functions by releasing a large