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Abstract
The View Of The Adipocyte As Simply A Storage Depot For Fat Is No Longer Tenable. Among The Various ”Adipocytokines,” Sdiponectin, Which Is An Abundant Circulating Protein Synthesized Solely In Adipose Tissue, Appears To Play A Very Important Role In Carbohydrate And Lipid Metabolism And Vascular Biology.
Adiponectin Appears To Be A Major Modulator Of Insulin Action And Its Levels Are Reduced In Type 2 Diabetes, Which Could Contribute To Peripheral Insulin Resistance In This Condition. It Has Significant Insulin-Sensitizing As Well As Anti-Inflammatory Properties That Include Suppression Of Macrophage Phagocytosis And TNF-o Secretion And Blockage Of Monocyte Adhesion To Endothelial Cells In Vitro.