الفهرس 
Introduction and Aim of The WorkOnly 14 pages are availabe for public view
 |  | from | 137 |  |  |
| | | from | 137 | | |
Abstract
The present study was undertaken to investigate \vhether garlic Joministration could nlodulate the changes induced by large and repeated doses of adrenal ine treatlllent in adult and senile male albino rats. An equal nunlber of senile nlale albino rats (Sprague-Dawly )train) were used throughout the present study. Both adult and senile rats were divided into 6 group of 8 rats each, kept in cages, fed on )tandard chow, given water ad libitum and acclimatized in the laboratory for two weeks before the start of experimentation.
Considering the same classification of adult and senile groups and the same treatment manner, the groups were used for experiments as follows: Group (1) served as control, group (2) was daily injected intraperitoneally with 0.6 mg/kg body weight of adrenaline (Memphes company, Cairo) for 28 successive days, group (3) was fed on the standard diet containing 20/0 garlic-bulb powder (standardized to 1.50/0 alliin, Sekem Phytopharmaceuticals, Cairo) for 28 days, group (4) received both adrenaline and garlic for 28 days, group (5) was firstly injected with adrenaline for the same experimental period and then left to rest for 15 days, and finally group (6) was injected with adrenaline for 28 days followed directly by 15 days of garlic administration.
Summarv At the end of the experinlental periods: anilnals were sacrificed r blood collection and imnlediateh dissected. The \vhole dorsal rtae; fronl the aortic arch to the iliac bifurcation; \vere isolated and ’ed for nlorphological and histological studies.
The results showed that adrenaline caused a significant decrease erythrocyte number, leucocytosis, and a slight decrease in platelet ount. Furthermore, it induced a decline in prothrombin time and oagulation time in both adult and senile animals. On the other hand,
~arlic treatment reduced the adrenaline effects on different cellular of blood and delayed the adrenaline-enhanced coagulation process. Although these counteracting effects of garlic were observed in both adult and senile rats, only blood hemoglobin concentration decreased significantly in all senile groups including those fed on garlic alone, a factor which considered as an adverse effect of such garlic dose used in the present study.
The protective effects of garlic against adrenalineeinduced unfavorable lipid changes in blood and dorsal aortae of adult and senile albino rats were also examined. The results showed that adrenaline treatment increased serum total lipids, triglycerides, total cholesterol and LDLLcholesterol. It also increased lipid precipitations and injuries in the tunica intima of the aortic wall. In contrary, garlic modulated these effects by decreasing total serum lipids, triglycerides,total cholesterol,LDL-cholesterol and
105
Sumlllary creas I n g H D L - cholesterol. A regressIon of aortic fatty streaks 5 also observed. These chan2es \i\ ere- rec02nized in both adult and
•... •...
nile rats compared to their control groups.
HO\VeVeL the animals responded differentially to the treatInent an age-dependent nlanner, where the response for garlic dose used the present study was less in senile anilnals than in adults. These ata indicate that garlic could iInprove the pathological effects of drenaline on blood and vascular wall lipids. Its concentration, eatment duration and age of the animal are important factors to be onsidered during garlic treatment.