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Abstract
Carnitine is a naturally occurring compound found in humans and other mammals.
It is a simple, vitamin-like compound that plays an essential role in the transfer of long chain fatty acids across the inner mitochondria membrane, in the detoxification of acylmoieties, and in maintaining normal levels of free coenzyme A Since carnitine metabolism reflects fatty acid metabolism, reduced carnitine level in the early neonatal period may affect fatty acid oxidation and thus be of potential pathophysiological relevance under conditions with higher energy demands e.g. in sepsis The aim of our study was to assess serum level of L-carnitine in healthy (Pre and full term) and septic (Pre and full term) neonates to study the effect of gestational age, birth weight and sepsis on serum level of Lcarnitine This study was conducted on 40 neonates recruited from NICU and nursery of Shebin El-kom Teaching Hosptial. They were 20 males and 20 females the range of their gestational age was 32 to 40 weeks They were divided into 3 groups: Group (1): Comprised 10 healthy full term neonates (5 males and 5 females) with a mean gestational age of 38.50 ± 0.85 wks and mean birth weight of (2.97 ± 0.3 kg).
Group(2)Comprised 10 healthy preterm neonates (5 males and 5 females) with mean gestational age of (33.60 ± 1.43 wks) and mean birth weight of(1.87 ± 0.27 kg.) Group (3): Comprised 20 septic neonates (9 full term and 11 preterm), with mean gestational age of (35.85 ± 2.96 wks) and