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Abstract
Chronic hepatitis (C) is the most common cause of chronic liver disease and cirrhosis, and the most common indication for liver transplantation in developed countries Several extrahepatic manifestations have been reported in the natural history of hepatitis (C) virus infection (HCV). Up to 40-74% of patients infected with HCV might develop at least one extrahepatic manifestation during the course of their disease. Mixed Cryoglobulinemia (MC) is the most known and studied syndrome associated with HCV infection. It is a systemic vasculitis that may involve the skin, kidney and nervous system. A frequent reported association is that between HCV infection and non-Hodgkin lymphoma. The cryoglobulinemia may be the intermediary disorder, in fact some persistent forms of cyoglobulinemia can switch over to a more aggressive haematologic disorder.The infected extrahepatic tissues might act as a reservoir for HCV and play a role in both HCV persistence and reactivation of infection.
HCV as an etiological agent replicating and expressing viral proteins in extrahepatic tissues itself contributes to EHM associated with chronic HCV infection.
This study was carried on 30 patients (with chronic (HCV)infection) , and 10 persons as control group matched by age and gender.